PuraStat®
E0060
PuraStat® is a synthetic haemostatic material in the form of a prefilled syringe.
PuraStat is indicated for haemostasis in the following situations encountered during surgery, when haemostasis by ligation or standard means is insufficient or impractical:
- Bleeding from small blood vessels and oozing from capillaries of the parenchyma of solid organs
- Oozing from vascular anastomoses
- Bleeding from small vessels and oozing from capillaries of the GI tract (reduction of delayed bleeding following gastrointestinal endoscopic submucosal dissection (ESD) procedures in the colon)
Beschrijving
PuraStat® Technology
The matrix is formed from synthetic peptides which are composed of three naturally occurring amino acids in a sequence which is repeated 4 times. The peptides self-assemble to form a 3 dimensional matrix upon a change in pH2 caused by exposure to an ionic solution such as blood, peritoneal fluid or other bodily secretions.
PuraStat® mimics extra cellular matrix
The peptides in PuraStat® are synthetized in a specific sequence which provide the molecule with shape memory to enable them to self assemble into a scaffold which mimics human extra cellular matrix (ECM).
Based on results of scanning electron microscopy, the structure of PuraStat® self-assembling peptide hydrogel is understood to be a network of fibres with a diameter of around 10–20 nm and pores with a diameter of about 50–200 nm that resembles the mesh structure of natural collagen.
Applying PuraStat® is simple
PuraStat® is a haemostat existing of a nanofiber network structure that requires no preparation. This means it is ready to apply straight from packet to patient.
To apply PuraStat® is just as easy, simply deploy PuraStat® at the base of the lesion and wait, following the instructions below:
- Remove as much blood as possible from haemorrhagic site.
- Apply an adequate quantity of PuraStat to the haemorrhagic site.
- The nozzle should be as close as possible to the bleeding point.
- Do not disturb the self-assembled PuraStat gel until sufficient time has been allowed for haemostasis to occur.
- If necessary, repeat the application of PuraStat several times until haemostasis is achieved.
- After haemostasis is confirmed, excess PuraStat may be left in place.
PuraStat proves to reduce the rate of delayed bleeding following colonic ESD*
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